Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 3.538


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
Tlx1 21908 T-cell leukemia, homeobox 1
Tlx3 27140 T-cell leukemia, homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tlx3chr11_-_33103458-0.082.9e-01Click!
Tlx1chr19_+_45225176-0.045.6e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_55223449 102.320 Sparc
secreted acidic cysteine rich glycoprotein
chr18_-_33623069 87.230 NM_001109990
 D0H4S114
DNA segment, human D4S114
chr14_+_102237708 75.775 Lmo7
LIM domain only 7
chr18_-_33623668 75.088 NM_001109988
 D0H4S114
DNA segment, human D4S114
chr6_+_17256383 66.222 Cav1
caveolin 1, caveolae protein
chr18_-_33623287 66.192 NM_053078
 D0H4S114
DNA segment, human D4S114
chr18_-_33623400 65.714 NM_001109989
 D0H4S114
DNA segment, human D4S114
chr6_+_17256415 65.080 Cav1
caveolin 1, caveolae protein
chr6_+_17256369 64.906 NM_007616
 Cav1
caveolin 1, caveolae protein
chr19_+_29999596 58.320 NM_133775
 Il33
interleukin 33
chr1_+_51345952 55.084 NM_138741
 Sdpr
serum deprivation response
chr3_+_90341208 51.572 S100a16
S100 calcium binding protein A16
chr8_-_87323896 50.963 Nfix
nuclear factor I/X
chr2_-_25325196 50.935 Ptgds
prostaglandin D2 synthase (brain)
chr1_+_51346086 50.927 Sdpr
serum deprivation response
chr5_-_116872852 50.512 NM_030704
 Hspb8
heat shock protein 8
chr11_-_116515602 49.383 NM_030206
 Cygb
cytoglobin
chr1_-_89470442 48.599 NM_001111314
 Ngef
neuronal guanine nucleotide exchange factor
chr4_-_115320309 48.141 NM_007823
 Cyp4b1
cytochrome P450, family 4, subfamily b, polypeptide 1
chr1_+_51346108 47.129 Sdpr
serum deprivation response

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 51 entries
Enrichment   P-value GO Accession GO Term
7.67 4.33e-02 GO:0046326 positive regulation of glucose import
7.13 5.71e-03 GO:0046324 regulation of glucose import
6.26 1.82e-02 GO:0010827 regulation of glucose transport
4.68 3.65e-02 GO:0048771 tissue remodeling
3.91 2.39e-02 GO:0006633 fatty acid biosynthetic process
3.85 3.68e-03 GO:0030324 lung development
3.79 4.59e-03 GO:0030323 respiratory tube development
3.39 2.09e-02 GO:0060541 respiratory system development
3.38 1.23e-02 GO:0019216 regulation of lipid metabolic process
3.35 4.21e-04 GO:0016053 organic acid biosynthetic process
3.35 4.21e-04 GO:0046394 carboxylic acid biosynthetic process
3.19 1.61e-02 GO:0042391 regulation of membrane potential
3.17 7.12e-04 GO:0006631 fatty acid metabolic process
3.00 6.23e-05 GO:0032787 monocarboxylic acid metabolic process
2.83 1.44e-02 GO:0030029 actin filament-based process
2.58 6.40e-03 GO:0035295 tube development
2.57 1.38e-04 GO:0044283 small molecule biosynthetic process
2.52 4.36e-02 GO:0030334 regulation of cell migration
2.44 3.58e-02 GO:0040012 regulation of locomotion
2.43 4.00e-02 GO:0001944 vasculature development

Gene overrepresentation in compartment category:

Showing 1 to 20 of 36 entries
Enrichment   P-value GO Accession GO Term
21.37 4.55e-02 GO:0005610 laminin-5 complex
12.67 4.46e-02 GO:0043256 laminin complex
11.87 9.16e-03 GO:0042589 zymogen granule membrane
4.93 2.10e-04 GO:0005604 basement membrane
4.42 4.73e-02 GO:0005901 caveola
4.18 1.57e-02 GO:0044309 neuron spine
3.90 8.92e-04 GO:0044420 extracellular matrix part
3.21 1.76e-06 GO:0005578 proteinaceous extracellular matrix
3.00 3.38e-06 GO:0031012 extracellular matrix
2.70 8.29e-04 GO:0030425 dendrite
2.60 2.41e-04 GO:0005625 soluble fraction
2.50 6.58e-12 GO:0044421 extracellular region part
2.49 5.45e-03 GO:0048471 perinuclear region of cytoplasm
2.45 3.98e-08 GO:0005615 extracellular space
2.41 6.69e-06 GO:0043005 neuron projection
2.36 1.33e-02 GO:0042598 vesicular fraction
2.33 2.29e-02 GO:0005792 microsome
2.22 1.98e-03 GO:0009986 cell surface
2.05 1.12e-07 GO:0000267 cell fraction
2.05 1.23e-05 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
Enrichment   P-value GO Accession GO Term
7.77 3.62e-02 GO:0005520 insulin-like growth factor binding
4.84 3.65e-02 GO:0016247 channel regulator activity
3.53 3.36e-02 GO:0019838 growth factor binding
3.50 1.05e-02 GO:0046906 tetrapyrrole binding
3.47 2.18e-02 GO:0020037 heme binding
1.38 5.23e-07 GO:0005515 protein binding
1.38 5.39e-03 GO:0046872 metal ion binding
1.36 8.17e-03 GO:0043167 ion binding
1.36 1.01e-02 GO:0043169 cation binding
1.23 1.12e-07 GO:0005488 binding